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Welcome to Mark Twain Brewing Company

Live Fully. Drink Responsibly.

cartoon beer mug with foam

mark twain brewing company. "go to heaven for the climate, hell for the company".



"My wife and I had a great meal here. Burger was delicious and the fried mushrooms we're pretty dang good. The red ale had a nice depth of flavor. The second floor has a nice view of the river."

☆ ☆ ☆ ☆ ☆

- Ryan M

"We had a birthday party here a couple of weeks ago, and wow this place went above and beyond. Sierra and Kat were amazing. What a team these two make. We got our drinks promptly, and the food was incredible. We couldn't have picked a better place to celebrate at. Thank you all for making my mom's birthday one of her best ones yet. We can't wait to come back."

☆ ☆ ☆ ☆ ☆

- Sara L

"Love it best pickle hard seltzer ever..... Great apps awesome help and the atmosphere is very peaceful music is not obnoxious all together great place your missing out of you don't stop in..... Just saying."

☆ ☆ ☆ ☆ ☆

- Jennifer B

Mark Twain Brewing Company

422 North Main Street
Hannibal, MO 63401
Tel: (573) 406-1300
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exterior view of mark twain brewery
outdoor dining on the deck
inside dining at mark twain brewery
a man sitting in an old car in front of mark twain brewing company